Your mini guide on Prostate Drugs

Prostate drugs are the drugs used for the treatment of prostate problems. With aging, there are 3 common prostate problems:

1. Prostatitis or inflammation of prostate gland

2. Enlarged prostate or Benign Prostatic Hyperplasia (BPH)

3. Prostate cancer

As the causes and manifestation of each prostatic problem differ, there are myriad drugs used nowadays for the treatment of prostatic diseases. The following paragraphs will give you the whole background of prostate drugs.

I. Prostatitis means that there is an inflammation in the prostate gland, which might occur due to infection with bacteria.

Actually, there are four types of prostatitis:


Type of prostatitis Treatment
Acutebacterial prostatitis

Highdoses of antibiotics taken from one to two weeks, then the dose arelowered and continued for several weeks.

Chronicbacterial prostatitis

High doses of antibiotics, but for longer period of time, for four to twelveweeks.

Chronicprostatitis/chronic pelvic pain syndrome I.Anti-inflammatory drugs to relief pain and inflammation.

II.Alpha-blockers to relax muscular tissue in the prostate to allow easypass of urine.


III. Antibiotics in case of undetected infection
Asymptomaticinflammatory prostatitis

Nodrugs are used, only repeated PSA test

II. Enlarged prostate or benign prostatic hyperplasia (BPH) is abnormal cellular growth (not cancer) of prostatic tissue. Myriad prostate drugs are used for the treatment of BPH.

Category Mode of action Generic name Brand name Side effects
Alpha-blockers

Relaxation of muscles surrounding the

Prostate gland

alfuzosin

doxazosin


doxazosin sustained

release

silodosin

prazosin1


tamsulosin

terazosin
Uroxatral

Cardura

Cardura XL

Rapaflo

Minipress

Flomax

Hytrin

-Vertigo

-Headache

-Stomach upset

-Decreased amount of semenwhen ejaculation occurs

 

5-alpha

Reductase inhibitors

Delays the growth of prostate and causes the shrinkage of

enlarged prostatic tissue byblocking a hormone

finasteride


dutasteride

Proscar or

Propecia

Avodart

-Lack of sexual desire.

-Reduced ability to ejaculateand failure tosustain ejaculation

-Problems of ejaculation

 

III. Prostate cancer occurs when abnormal cells undergo uncontrolled growth within prostatic tissue, forming a tumor mass. Usually, this type of abnormal cellular growth is supported by the male sex hormones (androgens), like testosterone and dihydrotestosterone (DHT). Hormone therapy (also known as androgen deprivation therapy (ADT) or androgen suppression therapy), are prostate drugs which can block or prevent the action of androgens.

It is proved clinically that reducing the levels of androgens in the body causes the cancer to shrink or delay its growth. Unfortunately, hormone therapy can’t cure the cancer completely.

In fact, hormone therapy is indicated in certain situations, including:

1- When surgical or radiation treatments fail to cure the cancer, because the cancer starts to metastasize outside the prostate.

2- Recurrent or persistent prostate cancers.

3- Hormone therapy is used as initial treatment combined with radiation therapy.

4- Prior of surgical or radiation treatments to enhance these treatments effects.

Though Orchiectomy or surgical castration is a surgical procedure, its effect resembles the effect of hormone therapy. In this type of surgery, the surgeon excises the testis (where 90% of androgens are formed), thus causing the prostate cancer to shrink or grow more slowly.

Types of prostate drugs used in hormonal manipulation are:

Category Mode of action Generic name Brand name Sideeffects
Luteinizinghormone-releasing hormone (LHRH) analogs Reducing theproduction of testosterone by the testicles (chemical castration) leuprolide

goserelin

triptorelin

histrelin
Lupron
Viadur
Eligard

Zoladex

Trelstar

Vantas

-Lossof sexual desire

-Impotence

-Hotflashings

-Painand growth of breast tissues

-Osteoporosis

-Anemia

-Decreasedin mental sharpness

-Elevatedblood cholesterol

-Developingdepression

Luteinizinghormone-releasing hormone (LHRH) antagonists Same like LHRH,but it seems to lower level of testosterone more rapidly, with lessflare ups of cancer

abarelix

degarelix

Plenaxis

Firmagon

-Weakness

-Increasein weight

-Lossof body muscular mass

-Highrisk for hypertension, diabetes, and myocardial infarctions

Anti-androgens Block or preventthe body from utilizing androgens flutamide

bicalutamide

nilutamide
Eulexin

Casodex

Nilandron

Sameside effects but with less sexual manifestations

-Diarrhea

-Nausea

-Liverimpairment

Estrogens androgen-suppressingdrugs

ketoconazole

Nizoral

-Bloodclotting

-Enlargementof the breast


Chemotherapy is indicated when prostate cancer starts to spread or metastasize to other organs or tissues. Chemotherapy involves the use of anti-cancerous drugs, which are injected into a blood vessel or taken orally. These kinds of prostate drugs have the power to destroy the growing cells in the body.

Some of chemotherapy drugs used might include:


Generic name

    Brand name

      Sideeffects

docetaxel

Taxotere

-Alopecia

-Lower immunity for infections

-Oral ulcers

-Losing apatite

-Vomiting

-High tendency for bleeding

-Tiredness

 

These side effects are short-term, andend once the chemotherapy is finished.

mitoxantrone

Novantrone

estramustine

Emcyt

doxorubicin

Adriamycin

etoposide

VP-16

vinblastine

Velban

paclitaxel

Taxol

carboplatin

Paraplatin

vinorelbine

Navelbine





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